About me

Hi, my name is Florian and I am currently working as a Postdoc at the institute for computational biomedicine in the group of Dr. Denis Schapiro. My current projects are focused on utilizing spatial OMICS to better understand cell-cell interactions in human diseases and how to utilize this exciting technology to better understand disease pathology. One of my key interests is the genetic basis of cardiovascular disease, particularly congenital heart disease, coronary artery disease and heart valve disease. I have utilized multi-OMICS, including highly-multiplexed imaging, single-cell technologies and CRISPR gene editing to better understand the molecular basis of these conditions and to identify potential treatment targets. During my PhD I have utilized whole-exome sequencing to identify candidate genes for congenital heart disease, helped in setting-up a single-cell platform (Drop-seq) and investigating a novel candidate gene for heart valve disease in the lab of Prof. Gregor Andelfinger at the CHU Ste Justine research center.

Beside my work, I am also extremely interested in using data science to analyze sports data, particularly football (soccer). I am a passionate supporter of Borussia Dortmund ever since I was young and love watching and playing soccer myself.

🧬 💻 👨‍🔬 🧪 🔬 ⚽ 🎮 🇩🇪


  • Spatial OMICS
  • Genetics
  • Cardiovascular health and disease
  • Data science & visualization
  • Football (soccer) data analysis


  • PhD in Life Sciences, 2018

    University of Muenster / CHU Ste Justine Research Center

  • MSc in Life Sciences, 2014

    University of Muenster

Skills & Interests


tidyverse, single-cell OMICS, genomics, building Rshiny apps, package building


basic computer vision, single-cell analysis

Ubuntu OS

My favourite OS


Molecular cloning, CRISPR, Rare & common diseases


Valve diseases, Coronary artery disease, Congenital heart diseases


Docker, Singularity, Nextflow

Education & research experience



Denis Schapiro Lab - Institute for Computational Biomedicine

Jan 2022 – Present Heidelberg


  • Spatial OMICS analysis of myocardial infarction
  • Development of new tools for highly-multiplexed image analysis
  • Development and maintenance of MCMICRO modules


Guillaume Lettre lab - Montreal Heart Institute

Aug 2018 – Aug 2021 Montreal


  • Endothelial dysfunction in coronary artery disease
  • Polygenic risk scores in coronary artery disease
  • Genetics of heart valve disease


University of Muenster / CHU Ste Justine Research Center

Apr 2014 – Apr 2018 Montreal

Title: The role of genetic factors in pathogenesis and progression of cardiac malformations


  • Whole exome sequencing in families with congenital heart disease
  • Establishing Drop-seq to study single-cell transcriptomics of the heart
  • Adamts19 as a novel candidate gene for heart valve disease


University of Muenster

Oct 2011 – Feb 2014 Muenster

Recent Posts

Predicting the Bundesliga table of the 2020/2021 season

In this blogpost, I predict the final table of the Bundesliga 2020/2021 season, compare it to clubs market value and to predictions from FiveThirty

Personal website is live

My personal website is finally online and live! You can find links to all of my online accounts and social media profiles, such as Github, Google Scholar, LinkedIN and Twitter on this site.


Soccer - Computer vision

Passion project on building soccer computer vision and data analysis tools for my local Montreal group


The Canadian Portal for Life Sciences Computing

Single Cell Analysis Portal (SCAP)

Rshiny app for single-cell analysis and visualization

Talks & Videos

Ozeki Journal club: 'Loss of ADAMTS19 causes progressive non-syndromic heart valve disease'

In this video, I joined my friends Carlos and Peri from Ozeki Inc. in a journal club session, to discuss one of my recent papers, on ADAMTS19 and heart valve genetics.
Ozeki Journal club: 'Loss of ADAMTS19 causes progressive non-syndromic heart valve disease'


CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions
Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease
Copy number variation analysis in bicuspid aortic valve-related aortopathy identifies TBX20 as a contributing gene
Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians